The analysis involving participants who completed the intervention produced similar results. In an intention-to-treat analysis, the weight regain was 0.93 kg less (95% CI, 0.31 to 1.55) in the groups assigned to a high-protein diet than in those assigned to a low-protein diet (P=0.003) and 0.95 kg less (95% CI, 0.33 to 1.57) in the groups assigned to a low-glycemic-index diet than in those assigned to a high-glycemic-index diet (P=0.003). In the analysis of participants who completed the study, only the low-protein–high-glycemic-index diet was associated with subsequent significant weight regain (1.67 kg 95% confidence interval, 0.48 to 2.87). The mean initial weight loss with the low-calorie diet was 11.0 kg. Fewer participants in the high-protein and the low-glycemic-index groups than in the low-protein–high-glycemic-index group dropped out of the study (26.4% and 25.6%, respectively, vs.ģ7.4% P=0.02 and P=0.01 for the respective comparisons). A total of 773 participants who completed that phase were randomly assigned to one of the five maintenance diets 548 completed the intervention (71%). Results A total of 1209 adults were screened (mean age, 41 years body-mass index, 34), of whom 938 entered the low-calorie-diet phase of the study. Participants were randomly assigned, in a two-by-two factorial design, to one of five ad libitum diets to prevent weight regain over a 26-week period: a low-protein and low-glycemic-index diet, a low-protein and high-glycemic-index diet, a high-protein and low-glycemic-index diet, a high-protein and high-glycemic-index diet, or a control diet. Methods We enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. 1 min - Uploaded by TanitaCorporationTanita's Healthy Edge Software is offered at no cost to you to Measure, Analyze, and Graph.
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